there are some general tips and tricks for Backup & Replication that are not directly related with Veeam Software. I will update this blog post from time to time to share these tips.
1) Format Backup Target disks with “/l” to avoid that NTFS blocks access to your very large and frequently updated (fragmented) backup files.
format /FS:NTFS /L
This will take a while and will overwrite the selected folume (data loss be carefull).
If you have Win7/Win2008R2 you need to first install the following patch: http://support.microsoft.com/kb/967351/en-us
2) Fix CPU load VMXnet3 network card bug if you use one virtualized backup server/role or an VM with high disk load: